Autophagy: a decisive process for stemness
نویسندگان
چکیده
Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective "clean-up" system is lost during aging, resulting in stem cell regenerative decline. Thus, autophagy is required for muscle stem cell homeostasis maintenance.
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2016